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We have characterized the flexibility of human amyloid P component (AP) in solution using molecular dynamics simulations. The estimated root mean square deviation for the C alpha atoms of the three-dimensional structure of AP is 4.9 A for a 1 ns molecular dynamics simulation. Analysis of the trajectory shows that the average backbone conformation is rigid; the largest relative motion of any C alpha is 0.6 A. The backbone of the B beta 1-B beta 2 loop exhibits large-scale sliding motions, whereas the C beta 1-C beta 2 loop of the C beta strands and the loop containing the solvent-exposed residues near the N terminus is also flexible. The B beta 1-B beta 2 loop assumes a turn-turn conformation and the C beta 1-C beta 2 loop a turn-curl conformation.The Duchess of Cambridge and her husband Prince William have been officially invited to the United States for the first time as head of state, as President Barack Obama prepares to make his first state visit to Britain.
The couple arrived in Washington late on Friday evening, following a ceremony to mark the anniversary of Winston Churchill’s death and talks with the US vice-president, Joe Biden, in which they were said to have had “lengthy conversations”.
In Britain, the duke and duchess were welcomed to the White House by Barack Obama, who referred to their “long history” in a speech to mark the death of the wartime prime minister.
Obama said: “That’s why it is fitting that just as our two nations celebrate the 50th anniversary of détente, the beginning of the most successful peace process in modern history, that they also commemorate the life of a man who believed so deeply in the promise of this continent that he dedicated his life to working for the people who call it home.
“His journey and his words live on, telling us that
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